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. 2022 Sep 22;11(1):2127282. doi: 10.1080/2162402X.2022.2127282

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© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — MbIL-2 activation of NK cells relies on classic IL-2 receptor signal transduction.

a: Representative flow cytometric analysis of NK-92-VEC and NK-92-mbIL-2 cells treated with tofacitinib. NK-92-VEC maintained with 200 U/ml IL-2 and add 1 μM tofacitinib for assays. NK-92-mbIL-2 maintained without IL-2 and add 1 μM tofacitinib for assays. b: Quantification and statistical analysis of data from A (n = 3). c: CCK8 assay of cell proliferation in NK-92-VEC and NK-92-mbIL-2 cells treated with tofacitinib (n = 6). NK-92-VEC maintained with 200 U/ml IL-2 and add 1 μM tofacitinib for assays. NK-92-mbIL-2 maintained without IL-2 and add 1 μM tofacitinib for assays.