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Drug Loading and Encapsulation Efficiency of Shikonin-Loaded MPEG-PCL Micelles
| Formulation No. | Shikonin (mg) | MPEG-PCL (mg) | Theoretical DL (%) | DL (%) | EE (%) |
|---|---|---|---|---|---|
| 1 | 0.25 | 12.0 | 2.04 | 0.88±0.08 | 43.08±3.77 |
| 2 | 0.5 | 12.0 | 4.00 | 1.21±0.13 | 30.30±3.23 |
| 3 | 1.0 | 12.0 | 7.69 | 1.35±0.11 | 17.55±1.41 |
| 4 | 2.0 | 12.0 | 14.29 | 1.42±0.06 | 9.91±0.39 |
Note: Results are presented as mean±SD, n=3.
Abbreviations: MPEG-PCL, methoxy poly (ethylene glycol) -b-poly (ε-caprolactone); DL, drug loading content; EE, entrapment efficiency.
