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. 2022 Jun 26;21(20):2179–2191. doi: 10.1080/15384101.2022.2092166

Figure 3.

Figure 3.

SP triggered pyroptotic cell death in asthma mice in a NK1R-dependent manner. (a) Overview of sensitization experiments in experimental asthma mice. (b-g): The mRNA expression of pro-inflammatory cytokines (TNF-α, TGF-β1, IL-2, IL-5, IL-18 and IL-1β) of asthma mice. (h-m): The expression levels of pro-inflammatory cytokines (TNF-α, TGF-β1, IL-2, IL-5, IL-18 and IL-1β) in serum of asthma mice. (n): The release of LDH was measured by LDH assay kit. (o): Immunofluorescence staining for Caspase-1 in airway epithelial were assessed. Each experiment was conducted in triplicate. *P < 0.05, ** P < 0.01, ***P < 0.001, ****P < 0.0001.