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. 2022 Sep 28;8(39):eabo1123. doi: 10.1126/sciadv.abo1123

Fig. 2. CJL causes an increase in tumor burden in K mice but has no impact on survival.

Fig. 2.

Five weeks after infection with lentivirus-Cre, K mice were placed in either 12:12LD or CJL for 20 weeks (A to F) or until signs of distress (G). (A) Representative H&E-stained sections at end point. Scale bars, 5000 μm. Tumor burden (B), numbers (C), size (D), and grade (E) were assessed from H&E sections. Column data represent means ± SEM. Values for individual animals (B, C, and E) or tumors (D) are plotted. (B and C) Clear and filled symbols represent males and females, respectively. *P < 0.05 by Mann-Whitney test. (F) Representative BrdU IHC images in tumors from K mice euthanized at ZT5 and quantitation of stained positive nuclei. Scale bar, 50 μm. (G) Kaplan-Meier survival analysis for K mice placed in 12:12LD (n = 19) or CJL (n = 19) conditions.