Table 3.
Predictors of COVID-19 after full vaccination among participants who received 3 vs. 2 doses of an mRNA vaccine.
| Number of events |
Number of events: COVID-19 severity based on chart review |
|||||||
|---|---|---|---|---|---|---|---|---|
| COVID-19 |
Symptomatic |
Moderate + severe + critical |
Severe + critical |
|||||
| aHR (95% CI) | p value | aHR (95% CI) | p value | aHR (95% CI) | p value | aHR (95% CI) | p value | |
| Total number of patients | 26,082 | 26,082 | 26,082 | 26,082 | ||||
| Number of events | 68 | 55 | 18 | 7 | ||||
| 2 Dose mRNA vaccine | 57 (0.44%) | 46 (0.35%) | 15 (0.12%) | 7 (0.05%) | ||||
| 3 Dose mRNA vaccine | 11 (0.08%) | 9 (0.07%) | 3 (0.02%) | 0 (0.00%) | ||||
| Vaccine | ||||||||
| 2 Dose mRNA vaccine | REF | REF | REF | REF | ||||
| 3 Dose mRNA vaccine | 0.19 (0.10–0.36) | <0.0001 | 0.19 (0.09–0.39) | <0.0001 | 0.20 (0.06–0.70) | 0.0113 | 0.00 (0.00–0.00) | <0.0001 |
| Age | 1.03 (0.99–1.06) | 0.1128 | 1.02 (0.99–1.06) | 0.2007 | 1.07 (1.02–1.12) | 0.0058 | 1.07 (1.01–1.13) | 0.0193 |
| Race other than non-Hispanic white | 1.51 (1.29–1.88) | 0.0150 | 1.55 (0.31–2.01) | 0.0905 | 1.35 (0.10–2.20) | 0.0946 | 1.30 (0.35–2.54) | 0.2677 |
| Alcohol-associated cirrhosis | 1.15 (0.55–1.62) | 0.8387 | 1.13 (0.51–1.70) | 0.8131 | 1.54 (0.18–2.58) | 0.2575 | 1.36 (0.14–2.12) | 0.2251 |
| Diabetes | 1.30 (0.80–2.11) | 0.2852 | 1.33 (0.77–2.28) | 0.3035 | 2.80 (0.88–8.92) | 0.0815 | 1.98 (0.83–11.81) | 0.4546 |
| Current/former smoker | 1.84 (0.51–2.37) | 0.4774 | 1.84 (0.49–2.44) | 0.5190 | 1.89 (0.33–2.41) | 0.8170 | 1.83 (0.43–2.61) | 0.9667 |
| Cirrhosis comorbidity | ||||||||
| 0 | REF | REF | REF | REF | ||||
| 1+0 | 1.34 (0.11–2.03) | 0.0574 | 1.23 (0.06–1.89) | 0.0330 | n.a. | n.a. | n.a. | n.a. |
| 1+1 | 1.78 (0.78–4.06) | 0.1696 | 1.54 (0.65–3.64) | 0.3217 | 2.44 (0.52–11.47) | 0.2599 | 2.35 (0.23–24.37) | 0.4736 |
| 3+0 | 1.35 (0.43–4.21) | 0.6058 | 1.56 (0.49–4.98) | 0.4558 | 2.85 (0.45–17.95) | 0.2644 | 1.97 (0.13–30.07) | 0.6261 |
| 3+1 | 1.91 (0.40–3.10) | 0.8307 | 1.92 (0.39–3.15) | 0.8393 | 1.09 (0.21–5.70) | 0.9227 | n.a. | n.a. |
| eCTP class | ||||||||
| A | REF | REF | REF | REF | ||||
| B or C | 1.58 (0.88–2.85) | 0.1267 | 1.48 (0.75–2.93) | 0.2547 | 1.04 (0.31–3.49) | 0.9468 | 1.14 (0.34–4.04) | 0.9929 |
Values in bold denote statistical significance.
Statistical method/test applied: Cox proportional-hazards model.
References were: race (non-Hispanic white); no alcohol-associated cirrhosis; no diabetes; non-smoker/former smoker.
aHR, adjusted hazard ratio; eCTP, electronic Child-Turcotte-Pugh.