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. 2022 Sep 27;11:e76835. doi: 10.7554/eLife.76835

Figure 4. Paradigm-induced activation patterns during baseline placebo.

Figure 4.

(a) Categorical effect of food stimulus presentation. Greater activity in the insula, amygdala, and orbitofrontal cortex was observed in the food compared to the non-food condition across both groups (N = 50; included contrast images: food > non-food). (b) Neural representation of preference values (parametric analysis). Regions in which the correlation with preference values was significant across participants included the ventromedial prefrontal cortex (vmPFC) and the bilateral nucleus accumbens (NAc) (included contrast images: all food × liking). (c) Sugar-specific blood oxygenation level-dependent (BOLD) signals in the vmPFC and right NAc. Bar plots show means and standard error of the mean (SEM) of contrast estimates extracted from peak voxels from the comparison HS > LS (included contrast images: HS × liking > LS × liking). All peaks and displayed p values are p < 0.05 FWE corrected. Activations are overlaid on a custom template (display threshold p < 0.005 uncorrected).