Table 4:
Percent of subjects with an abnormal mean or standard deviation for a given gas-transfer parameter as determined by the upper and lower limits of normal (in square brackets) for the healthy pediatric cohort. P-values (in parenthesis) are reported with respect to the pediatric healthy cohort and bolded when significant.
| Healthy Pediatric N = 5 [LLN - ULN] | BMT N = 12 % abnormal (P-value) | BPD N = 4 % abnormal (P-value) | CF N = 8 % abnormal (P-value) | chILD N = 5 % abnormal (P-value) | |
|---|---|---|---|---|---|
|
| |||||
| Ventilation | Mean [0.73–0.77] |
83%
(<0.001) |
25% (0.343) |
75%
(<0.001) |
80%
(<0.001) |
| Std. Dev. [0.10–0.17] |
50%
(<0.001) |
0% (1.000) |
63%
(<0.001) |
0% (1.000) |
|
| Dissolved (×10−3) |
Mean [6.3–11.8] |
58%
(<0.001) |
50%
(0.027) |
38%
(0.011) |
40%
(0.043) |
| Std. Dev. [0.5–2.2] |
25%
(0.035) |
25% (0.343) |
0% (1.000) |
40%
(0.043) |
|
| Barrier-uptake (×10−3) |
Mean [5.4–10.1] |
58%
(<0.001) |
25% (0.343) |
50%
(0.001) |
20% (0.407) |
| Std. Dev. [0.4–2.2] |
25%
(0.035) |
25% (0.343) |
0% (1.000) |
40%
(0.043) |
|
| RBC-transfer (×10−3) |
Mean [0.8–3.4] |
33%
(0.004) |
0% (1.000) |
50%
(0.001) |
0% (1.000) |
| Std. Dev. [0.3–0.9] |
42%
(<0.001) |
0% (1.000) |
25% (0.103) |
20% (0.407) |
|
| RBC:Barrier | Mean [0.12–0.45] |
25%
(0.035) |
25% (0.343) |
0% (1.000) |
20% (0.407) |
| Std. Dev. [0.04–0.13] |
17% (1.000) |
0% (1.000) |
0% (1.000) |
0% (1.000) |
|