Table 4.

Overall response (OR) rates and overall survival (OS) achieved in HIV negative and positive patients according to the treatment modalities used

Treatment	n	OR	P	Median OS ± SE (mos)	P
WBRT only
HIV−	11	6	NS	10.3 ± 4.5
HIV+	2	0		Not calculated
Chemotherapy only
HIV−	7	4	NS	21.3 ± 8.5	NS
HIV+	16	9		4.0 ± 4.3
WBRT + chemotherapy
HIV−	20	14	NS	23.8 ± 9.7	0.001
HIV+	9	5		3.4 ± 1.5
No treatment
HIV−	7			1.0 ± 10.9	NS
HIV+	14			0.7 ± 0.3

HIV− N = 45; HIV+ N = 41

SE standard error, WBRT whole brain radiotherapy

Chemotherapy regimens used: DeAngelis protocol, fludarabine + cytarabine, high dose methotrexate with or without temozolomide, Azidothymidine in combination with hydroxyurea or high dose methotrexate or high dose IL-2 + ganciclovir