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. 2022 Sep 6;99(10):e1067–e1078. doi: 10.1212/WNL.0000000000200832

Figure 3. Chord Diagrams Representing Connections Between Neuropathologic Lesions and Final Cognitive Diagnosis.

Figure 3

The weights of the connections represent the proportions of participants with LATE-NC/no HS, LATE + HS, and no LATE-NC/HS who were diagnosed with no cognitive impairment, CIND, or dementia (A) and the proportions of participants with moderate/severe ADNC/PART with and without LATE-NC who were diagnosed with no cognitive impairment, CIND, or dementia (B). Owing to the small sample size (n = 15), HS without LATE-NC is not included in the diagram; roughly equal numbers were diagnosed with no cognitive impairment, CIND, and dementia (n = 4, 6, and 5, respectively). Colors are presented only to distinguish between categories. ADNC = Alzheimer disease neuropathologic change; CIND = cognitive impairment, no dementia; HS = hippocampal sclerosis; LATE-NC = limbic-predominant age-related TDP-43 encephalopathy neuropathologic change; PART = primary age-related tauopathy.