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. 2022 Sep 29;253:189–196.e2. doi: 10.1016/j.jpeds.2022.09.039

Table II.

Clinical characteristics and outcomes of patient cases according to vaccination status

Characteristics/Outcomes Unvaccinated
Partially
Fully
P P
2848 (100) 459 (100) 398 (100)
Age (y)
 Mean (SD) 16.4 (2.3) 16.6 (2.0) 17.4 (2.0) <.0001
Age group (y)
 12-15 2664 (46.2) 575 (37.8) 314 (26.7) <.0001 <.0001
 16-17 1519 (26.4) 396 (26.0) 271 (23.0)
 18-19 1577 (27.4) 551 (36.2) 591 (50.3)
Period of admission
 Gamma/Delta 2062 (72.4) 179 (39.0) 41 (10.3) <.0001 <.0001
 Omicron 786 (27.6) 280 (61.0) 357 (89.7)
Sex
 Male 1505 (52.8) 277 (60.3) 263 (66.1) <.0001 <.0001
 Female 1343 (47.2) 182 (39.7) 135 (33.9)
Region
 Southeast 1336 (46.9) 211 (46.0) 210 (52.8) <.0001 .009
 South 575 (20.2) 91 (19.8) 84 (21.1)
 Central-West 307 (10.8) 44 (9.6) 27 (6.8)
 Northeast 393 (13.8) 66 (14.4) 57 (14.3)
 North 237 (8.3) 47 (10.2) 20 (5.0)
Ethinicity§
 White 1214 (51.8) 220 (52.9) 184 (56.4) .22 .21
 Brown Black 1093 (46.6) 184 (44.2) 137 (42.0)
 Asian 21 (0.9) 7 (1.7) 1 (0.3)
 Indigenous 17 (0.7) 5 (1.2) 4 (1.2)
Signs/symptoms at presentation
 Fever 1734 (60.9) 268 (58.4) 197 (49.5) <.0001 <.0001
 Cough 1814 (63.7) 258 (56.2) 227 (57.0) .001 .03
 Dyspneia 1438 (50.5) 180 (39.2) 146 (36.7) <.0001 <.0001
 Gastrointestinal 327 (11.5) 53 (11.5) 27 (6.8) .02 .85
Number of comorbidities
 None 2159 (75.8) 335 (73.0) 300 (75.4) .76 .96
 1 606 (21.3) 108 (23.5) 87 (21.9)
 2 83 (2.9) 16 (3.5) 11 (2.8)
Oxygen saturation <95%§
 Yes 1210 (54.5) 137 (39.8) 118 (41.4) <.0001 <.0001
ICU
 Yes 820 (28.8) 116 (25.3) 85 (21.4) .004 .03
Ventilatory support§
 None 1473 (56.2) 284 (68.4) 286 (72.6)
 Noninvasive 855 (32.6) 88 (21.2) 72(18.3) <.0001 <.0001
 Invasive 292 (11.1) 43 (10.4) 36 (9.1)
Severity index
 Mild 1190 (41.8) 248 (54.0) 222 (55.8)
 Moderate 1278 (44.9) 152 (33.1) 132 (33.2) <.0001 <.0001
 Severe 380 (13.3) 59 (12.9) 44 (11.1)
Outcomes§
 Discharge 2511 (89.6) 397 (88.4) 352 (88.4)
 Death 194 (6.9) 30 (6.7) 16 (4.0) .001 <.0001
 In-hospital 97 (3.5) 22 (4.9) 30 (7.5)

P, comparison among of 3 groups.

P, comparison between unvaccinated/partially vs fully vaccinated groups.

Gamma/Delta predominance (June 25, 2021, to December 24, 2021) and Omicron predominance (December 25, 2021, to March 28, 2022).

§

Missing data: Ethnicity, 618; Oxygen saturation, 855; Ventilatory support, 276; Outcomes, 56.

Severity index: mild (no need of oxygen support and no admission ICU), moderate (need of noninvasive oxygen support and admission in ICU), and severe (mechanical ventilation or death).