A comparison of serum magnesium levels (A), fractional excretion of magnesium (FEMg) (B), 24-hour urine magnesium levels (C), and supplemental dose of oral magnesium supplements (D) before and after initiation of empagliflozin. The solid red line represents average magnesium levels for respective columns. The dashed line at serum magnesium level of 1.7 mg/dL represents a lower limit of normal. Note: Patient 1 was dependent on intravenous magnesium sulfate infusions, which were discontinued after initiation of empagliflozin. Abbreviation: SGLT2, sodium-glucose cotransporter 2.