Table 3(C).
Association of LCH with solid tumors by age at LCH diagnosis and occurrence of AM with respect to LCH diagnosis.
| Age at LCH diagnosis |
||||||||
|---|---|---|---|---|---|---|---|---|
| ≤18 years |
>18 years |
|||||||
| Associated Malignancy |
Associated Malignancy |
|||||||
| Site/type of solid tumor | precedes | concurrent | follows | Total | precedes | concurrent | follows | Total |
| Lung | - | - | 1 | 1 | 5 | 9 | 9 | 23+3 |
| Carcinoma | - | - | 1 | 1 | 3 | 2 | 5 | 10 |
| Adenocarcinoma | - | - | - | - | 2 | 4 | 4 | 10 |
| Bronchiolo-alveolar carcinoma | - | - | - | - | - | 1 | - | 1 |
| Carcinoid tumor | - | - | - | - | - | 1 | - | 1 |
| Langerhans cell sarcoma | - | - | - | - | - | 1 | - | 1 |
| CNS | 5 | 1 | 8 | 14 | 1 | - | - | 1 |
| PNET | 2 | - | - | 2 | - | - | - | - |
| Astrocytoma | - | - | 1 | 1 | - | - | - | - |
| Germ cell tumor | 1 | - | - | 1 | - | - | - | - |
| Brain stem anaplastic tumor | - | 1 | - | 1 | - | - | - | - |
| Ependymoma | - | - | 3 | 3 | - | - | - | |
| Medulloblastoma | 2 | - | 1 | 3 | - | - | - | - |
| Meningioma | - | - | 2 | 2 | - | - | - | - |
| Oligodendroglioma | - | - | - | - | 1 | - | - | 1 |
| Paraganglioma | - | - | 1 | 1 | - | - | - | - |
| Skin | - | - | 4 | 4 | 3 | 2 | - | 5+2 |
| Basal cell carcinoma | - | - | 4 | 4 | 1 | 2 | - | 3 |
| Melanoma | - | - | - | - | 2 | - | - | 2 |
| Thyroid carcinoma | - | - | 2 | 2+1 | 3 | 4 | - | 7 |
| Breast carcinoma | - | - | 1 | 1 | 6 | - | - | 6+1 |
| Retinoblastoma | 3 | 1 | 2 | 6 | - | - | - | - |
| Bone | 1 | - | 6 | 7 | - | - | - | - |
| Osteosarcoma | - | - | 3 | 3 | - | - | - | - |
| Ewing sarcoma | 1 | - | 2 | 3 | - | - | - | - |
| Gigant cell tumor | - | - | 1 | 1 | - | - | - | - |
| Male genital system | - | - | - | - | 4 | - | - | 4+2 |
| Testicular teratoma | - | - | - | - | 1 | - | - | 1 |
| Testicular embrional carcinoma | - | - | - | - | 1 | - | - | 1 |
| Seminoma | - | - | - | - | 1 | - | - | 1 |
| Testicular germ cell tumor | - | - | - | - | 1 | - | - | 1 |
| Neuroblastoma | 2 | 3 | - | 5 | - | - | - | - |
| Gastro intestinal | - | - | - | - | 1 | 2 | - | 3 |
| Colon adenocarcinoma | - | - | - | - | 1 | 1 | - | 2 |
| Gastric carcinoma | - | - | - | - | - | 1 | - | 1 |
| Urinary tract | - | 1 | - | 1 | 1 | 2 | 1 | 4+1 |
| Renal carcinoma | - | - | - | - | - | 1 | 1 | 2 |
| Wilms tumor | - | 1 | - | 1 | - | - | - | - |
| Bladder carcinoma | - | - | - | - | 1 | - | - | 1 |
| Papillary urothelial carcinoma | - | - | - | - | - | 1 | - | 1 |
| Female genital system | - | - | - | - | 1 | - | 1 | 2 |
| Ovary dysgerminoma | - | - | - | - | 1 | - | - | 1 |
| Vulvar squamous cell carcinoma | - | - | - | - | - | - | 1 | 1 |
| Liver | - | - | 2 | 2 | - | - | - | - |
| Apudoma | - | - | 1 | 1 | - | - | - | - |
| Hepatocellular carcinoma | - | - | 1 | 1 | - | - | - | - |
| Pancreatic cancer | - | - | - | - | - | - | 1 | 1 |
| Parotid carcinoma | - | - | - | - | - | 1 | - | 1 |
| Malignant fibrous histiocytoma | - | - | - | - | - | - | 1 | 1 |
| Carcinoma of the tongue | - | - | - | - | - | 1 | - | 1 |
| Undefined carcinoma | - | - | - | - | - | 1 | 1 | 2 |
| Total | 11 | 6 | 26 | 43+1 | 25 | 22 | 14 | 61+9 |
Legend:
CNS: Central nervous system.
PNET: Primitive neuro-ectodermal tumor.
+n: number of malignancies subsequent to the first AM.