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. 2022 Sep 15;7(10):1516–1524. doi: 10.1038/s41564-022-01221-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 8 — Sub-strain variations over time for other individuals (K. pneumoniae). Figures were plotted for subjects with ≥2 single-strain timepoints. Coloured lines depict clusters of SNVs that were identified. Timepoints are shaded based on whether they were determined to be CPE colonized (red) or not (green). Note that similar to the observation in Extended Data Fig. 7, the dominant sub-strain in a subject can switch at timepoints that do not coincide with change in CPE colonization status (for example, V01 and V08 for 0507-T).

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