Fig. 2. Significance and explained variance of 12 clinical co-variates at different timepoints, modelled by ‘adonis’.

Bubbles show the amount of variance (R²) explained by each co-variate at a given timepoint and significant results (FDR < 0.05) are surrounded by a red box. a, Taxonomic profiles at the species level (n = 821). b, Functional metagenomic capacity at the enzyme level, using EC numbers (n = 821).