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. 2022 Sep 26;7(10):1525–1535. doi: 10.1038/s41564-022-01213-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a, NMDS plot of EC number profiles for all samples (n = 1,431) showing the mean centroid for each PGCT. The statistical significance was based on PERMANOVA, with permutations constrained within the patient. b,c, PLS-DA plots of metabolite profiles (n = 50) showing 95% confidence ellipses for each PGCT for stool (b) and serum (c). The statistical significance was based on PERMANOVA. d, NMDS plot of preterm intestinal organoid transcriptome profiles (n = 17; 2–3 per group) showing the mean centroid for each PGCT. CTRL, control. e, Venn diagram showing the number of DEGs compared with control for each PGCT. Zero values were removed for clarity.