Extended Data Fig. 7. Epitopes of representative mAbs of different RBD targeting antibody classes compared to the ACE2 binding surface and buried surfaces of RBD in closed and locked RBD ‘down’ spike trimers.

RBD molecular surfaces are colored in gray. Epitopes of a, R1-32, c, B38 (ref. ⁵⁹), d, C144 (ref. ²), e, S309 (ref. ⁶⁰), f, CR3022 (ref. ⁶¹), and the binding surface of g, ACE2 (ref. ⁵⁰) are highlighted in cyan. b, Epitopes of R1-32 (cyan) and substituted residues (red) in the Omicron BA.1 variant are highlighted. RBD surface areas buried by NTD in h, closed and i, locked spike trimers⁸ are highlighted in yellow.