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. 2022 Sep 23;7(10):1635–1649. doi: 10.1038/s41564-022-01235-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 8 — a, Pie charts showing the IGHV usage in healthy donors (HD, left), COVID-19 patients (middle), and published RBD targeting mAbs (right). Top 10 IGHVs are shown according to their rank in healthy donors. b, Three reading frames (RF1-3) of IGHD5-12 are shown. The GYSGYD motif is encoded by RF3. c, A summary of representative VH1-69 R1-32 like and R1-32 related mAbs reported from independent studies, except for 52, all are encoded by IGHV1-69, IGHD5-12, and IGLV1-40 and exhibit high sequence similarity to R1-32. d, Alignment of R1-32 like antibody light chain sequences. The RBD-contact residues in R1-32 and FC08 are colored in red with those involved in hydrogen-bonding underlined. The identical amino acid residues compared to the R1-32 light chain sequence are dotted.