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. 2022 Sep 23;7(10):1635–1649. doi: 10.1038/s41564-022-01235-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a–c, R1-32 (a), FC08 (b) and 52 (c) are antibodies of the newly defined R1-32-represented class. d–k, Reported class 2 VH1-69 antibodies. Except for k (C548), all shown VH1-69 antibodies interact with L452, F490 and L492 (the R1-32 HCDR2 epitope) using the hydrophobic HCDR2. Fab-VH, Fab-VL and RBD are coloured in magenta, purple and cyan, respectively. The green circles show the position of ACE2 when bound to RBD; the blue circles show the position of NTD in relation to an RBD in a ‘down’ position as illustrated in l. Epitopes of HCDR2 and hydrophobic residues involved in antibody-antigen interaction are shown in dashed boxes.