Table 1.

Cancer predisposition and related tumor-suppressor genes of constitutional RCs

RCs	Tumor-suppressor genes	Cancers	References
5	–	myelodysplastic syndrome	Nozawa et al.81
7	–	hyperpigmentation, melanoma	DeLozier-Blanchet et al.,109 Mehraein et al.109, 110
11	WT1	Wilms tumor	Carella et al.111
13	RB1	retinoblastoma	Morrissette et al.112
17	TP53, NF1	neurofibromatosis type 1	Havlovicova et al.85
21	RUNX1	acute myeloid leukemia	Burillo-Sanz et al.,113 Vormittag-Nocito et al.114
22	NF2	neurofibromatosis type II, meningiomas, schwannoma,	Tommerup et al.,115 Petrella et al.,116 Denayer et al.117