Table 1.
Genes affected by obesity across depots and species
| Gene | Mouse | Human | ||||||
|---|---|---|---|---|---|---|---|---|
| Subcutaneous | Visceral | Subcutaneous | Visceral | |||||
| Normal diet | High fat diet | Normal diet | High fat diet | BMI < 30 | BMI > 40 | BMI < 30 | BMI > 40 | |
| ADIPOQ | 4.18 | 1.35 | 4.66 | 1.62 | 9.81 | 4.93 | 13.71 | 5.19 |
| VEGFA | 6.11 | 4.55 | 6.01 | 3.42 | 1.54 | 1.15 | 1.43 | 0.80 |
| IGF1 | 5.67 | 4.13 | 7.44 | 2.63 | 4.56 | 1.21 | 5.02 | 0.86 |
| FGFR1 | 6.60 | 3.63 | 5.25 | 3.23 | 1.58 | 1.00 | 0.99 | 0.76 |
| MET | 1.74 | 1.02 | 1.91 | 1.06 | 0.18 | 0.10 | 0.32 | 0.14 |
| NAMPT | 1.22 | 0.88 | 1.09 | 0.73 | 1.76 | 0.54 | 0.74 | 0.30 |
| SCTR | 2.02 | 0.31 | 1.35 | 0.68 | 0.42 | 0.27 | 0.44 | 0.29 |
| PRLR | 0.35 | 0.15 | 3.68 | 0.93 | 0.02 | 0.01 | 0.04 | 0.01 |
Values were extracted from Supplementary Table 5 from Emont et al., representing average expression of genes in adipocyte clusters from mouse or human depots under different dietary conditions (mouse) or from individuals with different BMIs (human) [93]. Genes shown are all decreased by obesity. No genes were found to be increased by obesity across both depots in both species