Fig. 2.

CRC is associated with depletion of γδ T cells and Trm in colonic tissue and deficient regulatory function in CD4 Trm. A Numbers and percentages of γδ CD103⁺ T cells in IEL, alongside proportion of CD103 expression on total γδ T cells. B Numbers and percentages of CD8⁺ γδ TCR⁻ CD103⁺ Trm in IEL, alongside proportions expressing CD103 of total CD8 T cells. C Numbers and percentages of CD4⁺ CD103⁺ Trm in LPL, alongside proportions expressing CD103 of total CD4 T cells. D: Numbers and percentages of CD8⁺ CD103⁺ Trm in LPL, alongside proportions expressing CD103 of total CD8 T cells. E: Expression of regulatory T cell markers CD39 and CD73 on CD4 and CD8 Trm in LPL. HC: healthy controls, n = 13; CRC: colorectal cancer, n = 12. Median values ± 95% confidence intervals are shown; statistically significant differences between groups (Mann Whitney tests) are indicated