Table 1.
Patient characteristics
| Variables | Total N N (%) |
Gross total resection N (%) |
Subtotal resection N (%) |
|---|---|---|---|
| Number of patients | 373 | 238 (64) | 135 (36) |
| Median age | 63 (range: 18–89) | 64 | 63 |
| Gender | |||
| Female | 195 (52) | 123 (52) | 72 (53) |
| Male | 178 (48) | 115 (48) | 63 (47) |
| Preoperative ECOG performance status | |||
| 0 | 57 (15) | 41 (17) | 16 (12) |
| 1 | 145 (39) | 103 (43) | 42 (31) |
| 2 | 107 (29) | 65 (27) | 42 (31) |
| 3–4 | 64 (17) | 29 (12) | 35 (26) |
| Primary tumor | |||
| Lung | 134 (36) | 79 (33) | 55 (41) |
| Melanoma | 89 (24) | 59 (25) | 30 (22) |
| Colorectal | 39 (11) | 27 (11) | 12 (9) |
| Breast | 26 (7) | 22 (9) | 4 (3) |
| Kidney | 19 (5) | 13 (5) | 6 (4) |
| Other | 39 (11) | 26 (12) | 13 (10) |
| Unknown origin | 27 (7) | 12 (5) | 15 (11) |
| Extracranial metastases | |||
| Yes | 182 (49) | 117 (49) | 65 (48) |
| No | 172 (46) | 113 (47) | 59 (44) |
| Unknown | 19 (5) | 8 (3) | 11 (8) |
| Status of extracranial diseasea | |||
| Stable | 115 (31) | 81 (34) | 34 (25) |
| Progressive | 62 (17) | 41 (17) | 21 (16) |
| Synchronous | 125 (34) | 75 (32) | 50 (37) |
| Unknown disease status | 71 (19) | 41 (17) | 30 (22) |
| Location of brain metastasis | |||
| Infratentorial | 90 (24) | 59 (25) | 31 (23) |
| Supratentorial | 283 (76) | 179 (75) | 104 (77) |
| Median size (largest diameter) | 38 mm | 37 mm | 40 mm |
aStable: no documented new metastases or growing primary tumor in any imaging modality within the last 3 months prior to brain metastasis surgery. Progressive: growing primary tumor/metastases or new metastases 3 months prior to brain metastasis surgery. Synchronous: primary tumor discovered within 1 month prior to brain metastasis surgery/brain metastasis as first sign of disease. Unknown disease status: known primary cancer, but no radiological staging 3 months prior to brain metastasis surgery