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. 2022 May 8;164(10):2751–2765. doi: 10.1007/s00701-022-05225-7

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Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Relationship between proportion of findings and publication year, derived from multivariable meta-regression models additionally adjusted for age. Proportions on the y-axis relate to median age in the given analysis. Points show the findings of individual studies, with the size of the point relative to study sample size. Black lines are the fitted estimates, while the shaded area is the 95% confidence area of the fitted estimate