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Microglia have antigen-presenting functions. Both CD4 + and CD8 + T cells infiltrate key CNS areas of neurodegeneration in AD and PD. Genetic risk for both diseases has been identified in the region that codes for the MHC proteins, which present antigens to T cells. Microglia also produce cytokines that can support the survival and polarization of T cells. Aged microglia produce more IL-15, an activating T cell cytokine. The figure was made in BioRender
