Table 1.
Baseline characteristics of the study population.
| Entire cohort | Non-Hispanic White cohort | |
|---|---|---|
|
| ||
| Variables | N=1557 | N=1153 |
|
| ||
| Age (years) | 48.5 ± 11.5 | 50.7 ± 11.5 |
| Gender (female), n (%) | 989 (64) | 727 (63) |
| Type 2 diabetes n (%) | 560 (36) | 408 (35) |
| Hypertension, n (%) | 873 (56) | 685 (59) |
| Body mass index (kg/m2) | 34.4 ± 6.4 | 34.9 ± 6.4 |
| Waist circumference (cm) | 109.2 ± 14.3 | 110.4 ± 14.2 |
| Race/ethnicity, n (%) | ||
| Non-Hispanic White | 1153 (74) | - |
| Hispanic | 156 (10) | - |
| Non-Hispanic Black | 52 (3) | - |
| Non-Hispanic Asian | 106 (7) | - |
| Other or multiracial | 90 (6) | - |
| Non-heavy alcohol intake, (%) | 567 (36) | 433 (38) |
| Genetic variants, n (%) | ||
| PNPLA3 rs738409 | ||
| CC | 490 (31) | 377 (33) |
| CG | 680 (44) | 528 (46) |
| GG | 387 (25) | 248 (22) |
| HSD17B13 rs72613567 | ||
| −/− | 1028 (66) | 737 (64) |
| −/A | 446 (29) | 348 (30) |
| A/A | 83 (5) | 68 (6) |
| TM6SF2 rs58542926 | ||
| CC | 1005 (78) | 866 (76) |
| TC | 328 (21) | 254 (22) |
| TT | 24 (1) | 19 (2) |
| MBOAT7 rs641738 | ||
| CC | 511 (33) | 273 (24) |
| TC | 721 (46) | 550 (48) |
| TT | 325 (21) | 317 (28) |
| Lab reports | ||
| Alanine aminotransferase (U/L) | 72.0 ± 50.2 | 69.9 ± 47.2 |
| Aspartate aminotransferase (U/L) | 51.7 ± 33.0 | 51.3 ± 32.3 |
| Triglycerides (mg/dl) | 180.7 ± 166.1 | 185.6 ± 178.1 |
| Total cholesterol (mg/dl) | 192.0 ± 43.7 | 192.4 ± 44.3 |
| HDL cholesterol (mg/dl) | 43.7 ± 11.9 | 43.3 ± 11.6 |
| LDL cholesterol (mg/dl) | 115.8 ± 36.9 | 115.7 ± 37.3 |
| Histology reports | ||
| Steatosis, n (%) | ||
| <5% | 31 (2) | 21 (1.8) |
| 5–33% | 577 (37.1) | 420 (36.5) |
| 33–66% | 561 (36) | 413 (35.8) |
| >66% | 388 (24.9) | 299 (25.9) |
| Lobular inflammation, n (%) | ||
| No foci | 7 (0.4) | 2 (0.2) |
| <2 foci/200x | 783 (50.3) | 606 (52.6) |
| 2–4 foci/200x | 585 (37.6) | 419 (36.3) |
| >4 foci/200x | 182 (11.7) | 126 (10.9) |
| Ballooning, n (%) | ||
| None | 513 (33) | 383 (33.2) |
| Few | 444 (28.5) | 320 (27.8) |
| Many | 600 (38.5) | 450 (39) |
| Portal inflammation, n (%) | ||
| None | 184 (11.8) | 126 (10.9) |
| Mild | 994 (63.8) | 740 (64.2) |
| > Mild | 379 (24.4) | 287 (24.9) |
| Fibrosis stages, n (%) | ||
| 0 | 362 (23.2) | 258 (22.4) |
| 1 | 461 (29.6) | 313 (27.2) |
| 2 | 306 (19.7) | 238 (20.6) |
| 3 | 296 (19) | 227 (19.7) |
| 4 | 132 (8.5) | 117 (10.1) |
Quantitative variables are displayed as mean ± SD.