Table 4.

Covariate-adjusted^* correlations between all histological lesions. Results based on multivariable linear regression. Sensitivity analysis by each rs738409 genotype. NH-White population (n=1153).

		rs738409 CC genotype (n=377)
		Steatosis	Lobular inflammation	Ballooning degeneration	Portal inflammation	Fibrosis
Steatosis	Adj. β		0.12	0.08	−0.04	0.06
	P-value		0.004	0.137	0.287	0.450
Lobular inflammation	Adj. β			0.54	0.17	0.52
	P-value			<0.001	<0.001	<0.001
Ballooning degeneration	Adj. β				0.11	0.65
	P-value				0.004	<0.001
Portal inflammation	Adj. β					0.92
	P-value					<0.001
		rs738409 CG genotype (n=528)
Steatosis	Adj. β		0.16	0.07	−0.05	−0.19
	P-value		<0.001	0.095	0.047	0.002
Lobular inflammation	Adj. β			0.45	0.07	0.37
	P-value			<0.001	0.049	<0.001
Ballooning degeneration	Adj. β				0.10	0.61
	P-value				0.001	<0.001
Portal inflammation	Adj. β					0.93
	P-value					<0.001
		rs738409 GG genotype (n=248)
Steatosis	Adj. β		0.22	0.06	−0.16	−0.21
	P-value		<0.001	0.385	<0.001	0.031
Lobular inflammation	Adj. β			0.50	0.10	0.33
	P-value			<0.001	0.030	0.002
Ballooning degeneration	Adj. β				0.18	0.76
	P-value				<0.001	<0.001
Portal inflammation	Adj. β					0.94
	P-value					<0.001

^*Multivariable linear regression models adjusting for age, gender, BMI (kg/m²), T2DM, non-heavy alcohol intake, PNPLA3 rs738409, HSD17B13 rs72613567, TM6SF2 rs58542926, MBOAT7 rs641738.