Table 5.

Covariate-adjusted^* correlations between all histological lesions. Results based on multivariable linear regression. Sensitivity analysis by each rs738409 genotype. Other racial/ethnic groups (n=404).

		rs738409 CC genotype (n=113)
		Steatosis	Lobular inflammation	Ballooning degeneration	Portal inflammation	Fibrosis
Steatosis	Adj. β		0.22	0.02	−0.05	0.06
	P-value		0.022	0.849	0.497	0.645
Lobular inflammation	Adj. β			0.54	0.10	0.49
	P-value			<0.001	0.190	<0.001
Ballooning degeneration	Adj. β				0.18	0.67
	P-value				0.010	<0.001
Portal inflammation	Adj. β					0.54
	P-value					0.002
		rs738409 CG genotype (n=152)
Steatosis	Adj. β		0.06	−0.08	−0.03	−0.09
	P-value		0.441	0.369	0.613	0.417
Lobular inflammation	Adj. β			0.47	0.16	0.54
	P-value			<0.001	0.020	<0.001
Ballooning degeneration	Adj. β				0.03	0.70
	P-value				0.584	<0.001
Portal inflammation	Adj. β					0.69
	P-value					<0.001
		rs738409 GG genotype (n=139)
Steatosis	Adj. β		0.16	−0.11	−0.14	−0.24
	P-value		0.041	0.267	0.033	0.050
Lobular inflammation	Adj. β			0.31	0.09	0.31
	P-value			0.002	0.239	0.024
Ballooning degeneration	Adj. β				0.23	0.78
	P-value				<0.001	<0.001
Portal inflammation	Adj. β					0.75
	P-value					<0.001

^*Multivariable linear regression models adjusting for age, gender, BMI (kg/m²), T2DM, non-heavy alcohol intake, PNPLA3 rs738409, HSD17B13 rs72613567, TM6SF2 rs58542926, MBOAT7 rs641738, race/ethnicity.