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. 2022 Jul 16;127(7):1304–1311. doi: 10.1038/s41416-022-01913-4

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Actionable mutations grouped by RAS/RAF/MEK, PI3K/mTOR, HRR and RTK pathways. Percentage of patients with wild-type RAS/RAF plus at least one off-label indication was framed with dash line. b Comparison of percent pathway altered between the early-stage and the late-stage CRCs in MSI-H and MSS subtypes.