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. 2022 Jul 16;127(7):1304–1311. doi: 10.1038/s41416-022-01913-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Landscape of biomarker-guided drug grouping in early-stage CRCs. The actionable mutations are grouped by their corresponding targeted therapy drug type and broken down by OncoKB level of evidence in CRC. Samples are presented according to their highest level of evidence of actionability. b Upper portion, percentage of samples with given number of actionable genomic alterations per CRC actionability category. Lower portion, frequencies of actionable alterations in biomarker-guided drug grouping per CRC actionability category. c Percentage summary of actionable categories matched to the data from the OncoKB database.