Fig. 7. Intravenous injection of the multi-targeted CMV-siR^T+B+I circuit exerts a synergistic therapeutic effect against DSS-induced chronic UC.

a Flow chart of the experimental design. b Body weight curves (n = 6 in each group). c DAI scores (n = 6 in each group). d Representative macroscopic features of colons. Scale bar: 1 cm. e Determination of serum levels of IL-6, IL-12p70 and IL-17A by ELISA (n = 6 in each group). f Representative images of H&E staining of colon sections. Scale bar: 100 μm. g Histological scores of colon sections (n = 6 in each group). Values are presented as the mean ± SEM. Significance was determined using one-way ANOVA followed by Dunnett’s multiple comparison in (c, e, g) or two-way ANOVA followed by Dunnett’s multiple comparison in (b). *p < 0.05; **p < 0.01; ***p < 0.005.