Table 1.
Demographic characteristics, age ranges of study population, the corresponding changes of GFR, methods used to measure GFR.
| References | Sample |
Demographic characteristics |
Age range (years) |
Changes in GFR with age |
Methods used to analyze GFR |
|---|---|---|---|---|---|
| Davies et al. (21) | 70 healthy individuals | 100% male | 24–89 | GFR decline: from 122.8 to 65.3 mL/min/1.73 m2 (decreasing about 8 mL/min/1.73 m2 per decade) | Inulin clearance |
| Lindeman et al. (23) | 254 healthy kidney subjects (non-proteinuric diabetes were included) | 98% american predominately white | 22–97 | Creatinine clearence decline: 0.75 ml/min per year | Creatinine clearance |
| Fuiano et al. (24) | 26 living kidney donors | 100% males, young n = 15, older n = 11 | 19–32 65–76 |
GFR in young: 127 ± 5.8 mL/min/1.73 m2 GFR in older: 79 ± 4 mL/min/1.73 m2 |
Inulin clearance |
| Rule et al. (26) | 365 living kidney donors | 47.4% male, 80.3% white, age: 41.1 ± 11.4 yr |
18–71 | GFR decline: 4.9 mL/min/1.73 m2 per decade | Iothalamate clearance |
| Grewal et al. (29) | 428 living kidney donors (241 aged > 40 yr) | 49.1% male | 40–73 | GFR decline: 0.91 mL/min/1.73 m2 per decade | 51Cr-EDTA clearance |
| Poggio et al. (12) | 1,057 living kidney donors | 44% male, 11% African American | 38.5 ± 10.4 | GFR decline: 1.49 ± 0.61 ml/min/1.73 m2 per decade | 125I-Iothalamate clearance |
| Rule et al. (2) | 1,203 adult living kidney donors | 42% male, 93% white | 18–77 | GFR decline: 6.3 mL/min/1.73 m2 per decade | Iothalamate clearance |
| Kasiske et al. (27) | 201 kidney donors, 203 paired controls | 32% male | 43.1 ± 11.9 43.4 ± 11.3 | In kidney donors, GFR increased 1.47 ± 5.02 mL/min per year In controls, GFR declined 0.36 ± 7.55 mL/min per year |
Iohexol |
| Baba et al. (28) | 75,521 healthy individuals | 47% male | 42.8 ± 10.4 | eGFR decline: 1.07 ± 0.42 ml/min/1.73 m2per year. | 3-variable Japanese equation |
| Pottel et al. (30, 31) | 633 living kidney donors | 36.8% male | 20–>70 | GFR decline: 0.89 ml/min/1.73 m2 per year | Inulin, iohexol, or 51Cr-EDTA |
| Eriksen et al. (32) | 1,594 healthy individuals from the general population | 49% male 42% hypertension BMI:27.2 Kg/m2 UACR: 0.23 mg/mmol |
50–62 | GFR decline: 0.95 ± 2.23 ml/min/1.73 m2 per year | Iohexol clearance |
| Waas et al. (34) | 13,381 individuals from a German population cohort | 48.7% male 23.5% obese | 35–74 | eGFR decline: approximately 1 ml/min/1.73 m2 per year | eGFR calculated by CKD-EPI |