Table 3.
Summary of studies addressing equations to estimate glomerular filtration rate and participation of older individuals.
| References | eGFR equation | Sample size | Gold-standard | Conclusion |
|---|---|---|---|---|
| Levey et al. (83) | MDRD |
n = 1,628 n = 681 >55 yr n = 0 >70 yr |
125I-iothalamate | MDRD: more accurate than measured creatinine clearance (overestimates GFR by 19%) and Cockcroft-Gault formula (overestimates GFR by 16%). |
| Levey et al. (83) | CKD-EPI |
n = 8,254 n = 69 >75 yr |
125I-iothalamate | CKD-EPI: more accurate than MDRD. |
| Schaeffner et al. (77) | BIS 1 (creatinine) BIS 2 (cystatin C) |
n = 610 ≥70 years | Iohexol | BIS 2: lowest bias and smallest misclassification rate; BIS 1: smallest misclassification rate among the creatinine-based equations. |
| Grubb et al. (95) | CAPA |
n = 1,200 from a Swedish cohort and n = 413 from a Japanese cohort |
Inulin | Substandard P30 among the elderly (>80 years old) |
| Björk et al. (98) | LMR | n = 850 adults | Iohexol | Increased accuracy at measured GFR ≥90 mL/min/1.73 m2 The LM equations cannot be recommended for use in general clinical practice |
| Pottel et al. (100) | FAS |
n = 6,870 n = 1,774 ≥70 yr |
Inulin, iohexol and iothalamate | Less biased and more accurate than CKD-EPI for older adults. |
MDRD, Modification of Diet in Renal Disease; CKD-EPI, Chronic Kidney Disease-Epidemiology Collaboration; BIS, Berlin Initiative Study; CAPA, Caucasian, Asian, Pediatric and Adult; LMR, Lund-Malmö revised creatinine equation; FAS, Full Age Spectrum.