Table 4.
Studies comparing discrepancies of GFR estimating equations and estimated creatinine clearance (Cockcroft–Gault) in older adults examining performances between the eGFR analyzed by metrics such as bias, precision, and accuracy.
| Schaeffner et al. (77) | Bjork et al. (92) | Bjork et al. (93) | Selistre et al. (102) | |
|---|---|---|---|---|
| (A) Performances between the eGFR analyzed by median bias. | ||||
| n | 610 | 3,226 | 805 | 2,247 |
| Age (yr) | >70 | 70–89 | 74–93 | 65–90 |
| Cohort | The BIS cohort | 5 cohorts (Caucasian) | AGES-Reykjavik elderly cohort | Single center French cohort |
| Measured GFR | Plasma iohexol clearance | Plasma iohexol clearance | Plasma iohexol clearance | Inulin clearance |
| Cockcroft–Gault Cr | 2.53 (−4.06 to 9.21) | n.a | n.a | n.a |
| MDRDCr | 11.29 (3.85–17.68) | n.a | n.a | n.a |
| CKD-EPICr | 9.69 (2.45–15.49) | 3.6 (3.2–4.0) | 2.7 (2.1–3.3) | −2.0 (−3.0 to −1.0) |
| BIS-1 (Cr) | 0.80 (−5.03 to 6.11) | 1.7 (1.2–2.0) | n.a. | −2.0 (−3.5 to −1.5) |
| LMRCr | n.a | −0.7 (−1.0 to −0.4) | −4.8 (−5.4 to −4.2)a | 2.0 (1.5–3.5) |
| FASCr | n.a | 0.6 (0.3–0.9) | −5.7 (−6.3 to −5.1) a | 0.0 (−0.5 to 0.5) |
| CKD-EPICys | 2.05 (−3.23 to 8.61) | −2.7 (−3.1 to −2.3) | n.a | n.a |
| FASCys | n.a | −1.1 (−1.6 to −0.8) | n.a | n.a |
| CAPA (Cys) | n.a | −1.4 (−1.8 to −1.0) | n.a | n.a |
| CKD-EPICr+Cys | n.a | −0.1 (−0.4 to 0.2) | 0.6 (−0.1 to 1.2) | n.a |
| BIS-2 (Cr+Cys) | 0.87 (−4.40 to 4.98) | −1.2 (−1.5 to −0.8) | n.a | n.a |
| MEANLMR+CAPA | n.a | −1.0 (−1.3 to −0.6) | −2.7 (−3.2 to −2.1) a | n.a |
| FASCr+Cys | n.a | −0.8 (−1.1 to −0.5) | −5.9 (−6.5 to −5.4) a | n.a |
| (B) Performances between the eGFR analyzed by IQR–Precision. | ||||
| CKD-EPICr | n.a | 12.3 (11.9–13.0) | 12.1 (11.2–13.4) | 15.0 (14.5–17.0) |
| BIS-1 (Cr) | n.a | 11.6 (11.1–12.1) | n.a | 15.0 (14.0–16.5) |
| LMRCr | n.a | 10.5 (10.1–11.0) | 10.8 (10.1–11.5)b | 14.0 (13.0–15.5) |
| FASCr | n.a | 11.1 (10.6–11.5) | 10.7 (9.9–11.9)b | 14.0 (12.5–15.0) |
| CKD-EPICys | n.a | 11.8 (11.3–12.5) | n.a | n.a |
| FASCys | n.a | 12.2 (11.7–12.8) | n.a | n.a |
| CAPA (Cys) | n.a | 11.9 (11.3–12.6) | n.a | n.a |
| CKD-EPICr+Cys | n.a | 10.2 (9.6–10.8) | 10.2 (9.0–11.1) | n.a |
| BIS-2 (Cr+Cys) | n.a | 10.5 (10.0–11.0) | n.a | n.a |
| MEANLMR+CAPA | n.a | 9.2 (8.8–9.6) | 9.3 (8.5–10.1)c | n.a |
| FASCr+Cys | n.a | 10.1 (9.7–10.7) | 10.0 (9.1–10.9)c | n.a |
| (C) Performances between the eGFR analyzed by P30 accuracy. | ||||
| Cockcroft–GaultCr | 87.4 | n.a | n.a | n.a |
| MDRDCr | 70.9 | n.a | n.a | n.a |
| CKD-EPICr | 77.9 | 76.4 (74.9–77.9) | 91.7 (89.9–93.4) | 77.0 (73.0–80.0) |
| BIS-1 (Cr) | 95.1 | 77.5 (76.1–78.9) | n.a. | 76.0 (72.5–79.5) |
| LMRCr | n.a | 83.5 (82.2–84.8) | 95.0 (93.5–96.5)b | 80.0 (76.5–83.5) |
| FASCr | n.a | 80.9 (79.5–82.3) | 95.8 (94.4–97.2)b | 78.5 (75.0–82.0) |
| CKD-EPICys | 89.1 | 78.8 (77.3–80.4) | n.a | n.a |
| FASCys | n.a | 80.9 (79.4–82.4) | n.a | n.a |
| CAPA (Cys) | n.a | 80.3 (78.8–81.8) | n.a | n.a |
| CKD-EPICr+Cys | 86.8 (85.5–88.1) | 96.1 (94.8–97.4) | n.a | |
| BIS-2 (Cr+Cys) | 96.1 | 85.7 (84.4–87.0) | n.a | n.a |
| MEANLMR+CAPA | n.a | 88.7 (87.5–89.9) | 97.3 (96.2–98.4)b | n.a |
| FASCr+Cys | n.a | 85.7 (84.4–87.1) | 97.8 (96.7–98.8)b | n.a |
a
Significantly worse (P < 0.05) than corresponding CKD-EPI equation.
b
Significantly better (P < 0.05) than corresponding CKD-EPI equation.
c
No statistical difference (P < 0.05) compared with corresponding CKD-EPI equation.