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. 2022 Sep 15;16:1000304. doi: 10.3389/fnins.2022.1000304

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Copyright © 2022 Valderrama, de la Torre and McAlpine.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Figure adapted from Monaghan et al. (2020) presenting a model for synaptopathy and central gain activation. (A) The loss of high-threshold auditory nerve fibers in cochlear synaptopathy saturates the spiking probability of neurons in the inferior colliculus at supra-threshold level. (B) Central gain activation presents a multiplicative increase of the neurons sensitivity to restore the maximum (non-synaptopathic) spike probability. (C,D) As a consequence, the slope of the spike probability function increases in mid-levels, which leads to better discriminability from the HHL model (squares) than from the control model (circles) at 60 dB SPL, but reduced discriminability at 75 dB SPL.