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. 2022 Sep 15;13:949396. doi: 10.3389/fendo.2022.949396

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Copyright © 2022 Kavarthapu and Dufau

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcriptional regulation of hPRLR induced by E2. E2 induces ligand mediated ERα-Sp1-C/EBPβ complex formation and binding to the hPIII promoter of the hPRLR gene (38, 39). This results in increased transcription of PRLR. PRL/PRLR activates JAK/STAT that can induce the transcription of ERα. P4 (progesterone)/Prog receptor can induce transcription of PRLR through association with Sp1and C/EBPβ through promoter hPIII.