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. 2022 Sep 15;13:925690. doi: 10.3389/fimmu.2022.925690

Table 4.

Threshold effect analysis of SII on CAP using two-piecewise linear regression model.

CAP (dB/m) Adjusted β (95% CI)P value
SII
Inflection point 687.059
SII<687.059 (1,000 cells/µl) 0.026 (0.017, 0.035) <0.0001
SII>687.059 (1,000 cells/µl) -0.008 (-0.015, -0.002) 0.0107
Log likelihood ratio <0.001
Men
Inflection point 591.000
SII<591.000 (1,000 cells/µl) 0.045 (0.029, 0.062) <0.0001
SII>591.000 (1,000 cells/µl) -0.008 (-0.019, 0.003) 0.1556
Log likelihood ratio <0.001
Women
Inflection point 749.692
SII<749.692 (1,000 cells/µl) 0.022 (0.011, 0.033) 0.0001
SII>749.692 (1,000 cells/µl) -0.008 (-0.016, -0.000) 0.0372
Log likelihood ratio <0.001

Age, gender, race, educational level, BMI, family income-to-poverty ratio, moderate activities, smoking status, ALP, ALT, AST, total calcium, total cholesterol, triglyceride, LDL, HDL-C, waist circumference, and serum phosphorus were adjusted.

LSM, liver stiffness measure ; SII, systemic immune-inflammation index.