Table 2.
Antidepressant medications prescribed to the 500 patients in the antidepressant group at the time of admission to the hospital, and hazard ratios for death in those prescribed individual antidepressants or classes of antidepressants vs. those not prescribed antidepressants.
|
Hazard ratioc (95% CI) |
||||
|---|---|---|---|---|
| Dose, mg | vs. non-antidepressant | vs. non-antidepressant | ||
| Antidepressant medication | No.a (%) | median (IQR)b | Group 1 | Group 2 |
| Selective serotonin reuptake inhibitors | ||||
| Citalopram | 61 (12.2) | 20 (10, 20) | 0.86 (0.39, 1.9) | 0.77 (0.35, 1.7) |
| Escitalopram | 47 (9.4) | 10 (10, 20) | 1.9 (0.99, 3.5) | 1.7 (0.89, 3.1) |
| Fluoxetine | 57 (11.4) | 20 (20, 40) | 0.94 (0.35, 2.5) | 0.83 (0.31, 2.2) |
| Paroxetine | 24 (4.8) | 25 (20, 40) | 0.57 (0.15, 2.2) | 0.51 (0.13, 1.9) |
| Sertraline | 127 (25.4) | 50 (50, 100) | 0.98 (0.59, 1.7) | 0.87 (0.53, 1.4) |
| Any selective serotonin reuptake inhibitor | 313 (62.6) | 1.00 (0.67, 1.5) | 0.89 (0.61, 1.3) | |
| Sigma-1 receptor agonist (citalopram, escitalopram, or fluoxetine) | 164 (32.8) | 1.2 (0.69, 2.0) | 1.03 (0.62, 1.7) | |
| Serotonin-norepinephrine reuptake inhibitors | ||||
| Duloxetine | 73 (14.6) | 60 (30, 60) | 1.1 (0.55, 2.3) | 1.01 (0.49, 2.1) |
| Venlafaxine | 39 (7.8) | 75 (75, 150) | 2.2 (1.1, 4.3) | 1.9 (1.00, 3.8) |
| Any serotonin-norepinephrine reuptake inhibitor | 111 (22.2) | 1.6 (0.95, 2.7) | 1.4 (0.86, 2.4) | |
| Mirtazapine | 128 (25.6) | 14 (7.5, 15) | 1.7 (1.1, 2.7) | 1.5 (1.01, 2.4) |
IQR, interquartile range.
a
54 patients were prescribed two antidepressants, and one patient was prescribed three antidepressants.
b
Number of patients with missing dose information: citalopram (2); escitalopram (3); fluoxetine (2); paroxetine (2); sertraline (4); duloxetine (3); venlafaxine (2); mirtazapine (5).
c
Estimate adjusted for age, sex, race, ethnicity, co-occurring disorders, and secular time period.