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. 2022 Sep 15;13:985954. doi: 10.3389/fphar.2022.985954

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Copyright © 2022 Vengeliene and Spanagel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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No development of tolerance with repeated administration of mGlu2/3 agonist during relapse-like alcohol consumption in male rats. Alcohol consumption was calculated in g of pure alcohol per kg of body weight per day and presented as the average daily intake during weeks 50–64 of voluntary alcohol drinking interrupted with deprivation phases (seventh, eighth, and ninth EtOH deprivation). Administration of either vehicle (n = 8) or 5 mg/kg of LY354740 (n = 7) started on the last day of the seventh alcohol deprivation period, which was introduced following week 52 of access to alcohol. Each animal was given five injections every 12 h before and during three subsequent post-abstinence drinking phases. Data are presented as means ± S.E.M.