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. 2022 Sep 15;13:985954. doi: 10.3389/fphar.2022.985954

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Copyright © 2022 Vengeliene and Spanagel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of the mGlu2 PAM LY487379 on relapse-like alcohol consumption in male and female rats and on water consumption in male rats. Total alcohol intake (g/kg/day) before (shown as the average of the last 3 days of baseline drinking (BL) and after an alcohol deprivation period of 2 weeks. Arrows indicate a total of five, once every 12 h, administrations of either (A) vehicle (n = 8), 10 mg/kg of LY487379 (n = 7), or 30 mg/kg of LY487379 (n = 7) in male rats, and (C) vehicle (n = 8) or 30 mg/kg of LY487379 (n = 10) in female rats. All animals were re-exposed to alcohol immediately after the second drug administration. In (B,D) total water intake (ml/kg/day) before (shown as the average of the last 3 days, BL) and after an alcohol deprivation period of 2 weeks is shown. Data are presented as means ± S.E.M. * indicates significant differences from the vehicle group and + indicates significant difference from baseline, p < 0.05.