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. 2022 Sep 15;13:985954. doi: 10.3389/fphar.2022.985954

FIGURE 5.

FIGURE 5

Effects of mGlu2/3 agonists (LY379268 and LY354740), mGlu2 PAM (LY487379) and agonist + PAM combinations on locomotor activity in male rats. Locomotor activity is shown as 12-h post-injection intervals of the animals’ active phase. The percentage of each rat’s locomotor activity during and after treatment days was calculated with respect to basal activity prior to treatment (average of the last 3 days, dashed line). Each animal was given a total of five injections every 12 h (injection days are marked as “^“) of either (A) vehicle (n = 8), 1 mg/kg of LY379268 (n = 8) or 3 mg/kg of LY379268 (n = 8) (B) vehicle (n = 10), 3 mg/kg of LY354740 (n = 8) or 10 mg/kg of LY354740 (n = 7) (C) vehicle (n = 8), 10 mg/kg of LY487379 (n = 7) or 30 mg/kg of LY487379 (n = 7) and (D) combination of Vehicle1 (n = 8) used for LY379268 with Vehicle2 (n = 8) used for LY487379; 0.3 mg/kg of LY379268 with 10 mg/kg of LY487379 (n = 8); 1 mg/kg of LY379268 with 10 mg/kg of LY487379 (n = 8); and 3 mg/kg of LY379268 with 10 mg/kg LY487379 (n = 8). All animals were re-exposed to alcohol immediately after the second drug administration. Data are presented as means ± S.E.M.