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. 2022 Sep 24;57:102491. doi: 10.1016/j.redox.2022.102491

Fig. 3.

Fig. 3

Impact of sexual dimorphism on the MEE proteome profiles of mice treated with different concentrations of ascorbate. (A) PCA graph of Gulo−/− mice treated with 0.4% ascorbate in drinking water since weaning compared to age-matched control untreated WT mice in both females and males. (B) PCA graph of Gulo−/− mice treated with different concentrations of ascorbate in drinking water demonstrating the difference between males and females. F = Females and M = males; WT00 = WT females or males with no ascorbate for 4 months; WT40 = WT females or males treated with 0.4% ascorbate for 4 months; GL00 = Gulo−/− females or males with no ascorbate for 1 month; GL01 = Gulo−/− females or males treated with 0.01% ascorbate for 4 months; GL05 = Gulo−/− females or males treated with 0.05% ascorbate for 4 months; GL40 = Gulo−/− females or males treated with 0.4% ascorbate for 4 months; GLR40 = Gulo−/− females or males treated with 0% ascorbate for 1 month followed by 1 month of 0.4% ascorbate treatment.