Fig. 4.

Impact of ascorbate on the MEE proteome profiles of females and male mice. (A) PCA graph of untreated WT and Gulo^−/− females treated with different concentrations of ascorbate in drinking water. (B) PCA graph of untreated WT and Gulo^−/− males treated with different concentrations of ascorbate in drinking water. The ellipses on the graphs represent the areas in which additional mice of the same group would fall based on their MEE proteome profile with a probability of 95%. (C) Venn diagram showing the number of proteins uniquely or commonly affected in male and female mice.