Table 2.
Gene ontology analyses of proteins that correlated with liver ascorbate levels in female or male mice.
| Positive correlation in females | Bonferroni p-value | Proteins |
|---|---|---|
| Mitochondrial electron transport, ubiquinol to cytochrome c | 1.75E-08 | Uqcrb, Uqcrq, Uqcrc1, Cycs, Uqcrfs1, Uqcr10 |
| Steroid metabolic process | 8.54E-06 | Cyp39a1, Cyb5r3, Cyp2b10, Akr1c14, Sult2a8, Ugt2b5, Dhcr24, Cyp17a1 |
| Lipid metabolic process | 4.07E-04 | Cyp39a1, Fads2, Sult1d1, Cyb5r3, Sult2a8, Ugt2b5, Apoc3, Dhcr24, Ugt1a9, Acacb, Mgll, Cyp17a1 |
| Xenobiotic metabolic process | 0.00126 | Cyp2c69, Cyp2d9, Cyp2a4, Cyp2b10, Sult2a8, Cyp2f2 |
| Organic acid metabolic process | 0.00218 | Cyp2c69, Cyp2d9, Cyp2a4, Cyp2b10, Cyp2f2 |
| Epoxygenase P450 pathway | 0.02889 | Cyp2c69, Cyp2a4, Cyp2b10, Cyp2f2 |
| Inverse correlation in females | Bonferroni p-value | Proteins |
| RNA splicing | 0.00178 | Hnrnpm, Ddx39b, U2af2, Luc7l3, U2af1, Hnrnpa1, Snrnp200, Sf3b1, Prpf8 |
| Innate immune response | 0.00702 | Fgb, C4b, Ighg2b, Apcs, Ighg2c, Anxa1, Cfh, Pld4, S100a9, S100a8, Mbl1, Mbl2 |
| mRNA processing | 0.01205 | Hnrnpm, Ddx39b, U2af2, Luc7l3, U2af1, Hnrnpa1, Snrnp200, Sf3b1, Prpf8 |
| Positive correlation in males | Bonferroni p-value | Proteins |
| Mitochondrial electron transport, ubiquinol to cytochrome c | 7.74E-08 | Uqcrq, Uqcrc1, Uqcrfs1, Uqcr10, Cyc1 |