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. 2022 Sep 15;14:993615. doi: 10.3389/fnagi.2022.993615

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Copyright © 2022 Chu, Hou, Meng, Croteau, Wei, De, Becker and Bohr.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Enterotypes of the gut microbiome differed between Alzheimer’s disease (AD) and wild-type (WT) mice. (A) Enterotype analysis at the genus level of the gut microbiomes of AD mice (n = 9, 6 males and 3 females, 12-month-old) and WT mice (n = 11, 9 males and 3 females, 12-month-old). The data were most naturally separated into three clusters, as determined by the Calinski–Harabasz (CH) index and represented using principal coordinate analysis (PCoA). The corresponding phylum is labeled by colors separately. (B–D) Representative genera of each enterotype: Enterotype 1 is represented by Prevotella, Enterotype 2 is represented by Bacteroides, and Enterotype 3 is represented by Odoribacter. Data are shown as all samples with a boxplot. F, females; M, males. *P < 0.05, **P < 0.01, one-way analysis of variance (ANOVA) followed by Tukey’s multiple comparisons.