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. 2022 Sep 15;14:993615. doi: 10.3389/fnagi.2022.993615

FIGURE 6.

FIGURE 6

Microbial communities changed after 1 and 8 weeks of nicotinamide riboside (NR) treatment. (A,B) Microbiome composition at the phylum level on Day 7 (A) and Day 56 (B). (C–F) The changes in relative abundances of Actinobacteria and Verrucomicriobia on Day 7 (C,D) and Day 56 (E,F) (n = 3–6). Data showed as mean ± SD. *P < 0.05, two-way analysis of variance (ANOVA) followed by Tukey’s multiple comparisons. (G–I) The changes in relative abundances of Bacteroidetes (G), Firmicutes (H), and the F/B ratio (I) on Day 56 (n = 3–6). Data showed as mean ± SD. *P < 0.05, two-way ANOVA followed by Tukey’s multiple comparisons. (J,K) Enterotype analysis at the genus level of the gut microbiomes on Day 7 (J) and Day 56 (K), respectively. The data are most naturally separated into three clusters, as determined by the CH index and represented using principal coordinate analysis (PCoA) (n = 3–6). Data are shown as all samples with a median value. *P < 0.05. For Day 7, WT-Veh (5 males and 1 female), WT-NR (4 males and 2 females), AD-Veh (3 males and 1 female), AD-NR (3 males and 2 female), 10-month-old; For Day 56, WT-Veh (4 males and 1 female), WT-NR (4 males and 2 females), AD-Veh (2 males and 1 female), AD-NR (2 males and 1 female), 12-month-old.