TABLE 2.
The relative abundance (%) of species at family level.
| Family | WT-Veh | WT-NR | AD-Veh | AD-NR |
| f__Coriobacteriaceae | 0.82 ± 0.38* | 0.87 ± 0.35 | 0.37 ± 0.29 | 1.39 ± 0.36** |
| f__Rikenellaceae | 2.99 ± 1.7 | 2.79 ± 1.29 | 2.72 ± 1.55 | 2.71 ± 0.33 |
| f__Lachnospiraceae | 9.14 ± 2.98 | 12.17 ± 4.9 | 9.32 ± 1.01 | 14.05 ± 2.68* |
| f__Helicobacteraceae | 1.84 ± 1.14 | 4.75 ± 6.07 | 2.52 ± 0.99 | 2.81 ± 0.71 |
| f__S24.7 | 45.18 ± 2.51** | 38.8 ± 7.74 | 35.28 ± 8.1 | 39.91 ± 3.22* |
| f__Ruminococcaceae | 7.19 ± 1.31* | 9.9 ± 3.55 | 5.38 ± 1.5 | 11.57 ± 1.08** |
| f__Lactobacillaceae | 4.56 ± 1.66 | 2.52 ± 1.82 | 4.86 ± 4.96 | 2.75 ± 0.88 |
| f__Desulfovibrionaceae | 0.88 ± 0.14* | 0.81 ± 0.59 | 0.37 ± 0.21 | 1.21 ± 0.44* |
| f__Bifidobacteriaceae | 1.04 ± 0.8 | 0.62 ± 0.67 | 0.47 ± 0.36 | 0.58 ± 0.82 |
| f__Mogibacteriaceae | 0.26 ± 0.07 | 0.29 ± 0.14 | 0.28 ± 0.09 | 0.47 ± 0.32 |
| f__Alcaligenaceae | 5.32 ± 4.35 | 5.02 ± 1.7 | 4.63 ± 1.94 | 5.02 ± 0.43 |
| f__Odoribacteraceae | 2.76 ± 2.51 | 2.11 ± 0.89 | 1.47 ± 0.32 | 5.04 ± 2.1 |
| f__Erysipelotrichaceae | 2.54 ± 1.73 | 2.38 ± 1.44 | 2.6 ± 0.78 | 2.32 ± 1.56 |
| f__Clostridiaceae | 0.74 ± 0.97 | 0.67 ± 1.17 | 0.01 ± 0.02 | 0.65 ± 0.95 |
| f__Deferribacteraceae | 0.31 ± 0.42 | 0.22 ± 0.14 | 0.09 ± 0.13 | 0.32 ± 0.15* |
| f__Bacteroidaceae | 2.53 ± 1.11* | 3.35 ± 3.22 | 4.33 ± 3.05 | 2.89 ± 1.82* |
| f__Porphyromonadaceae | 1.96 ± 0.74 | 2.36 ± 1.07 | 2.6 ± 2.5 | 1.44 ± 0.11 |
| f__Turicibacteraceae | 0.76 ± 0.51 | 1.12 ± 1.79 | 0.14 ± 0.28 | 0.73 ± 1 |
| f__Prevotellaceae | 0.54 ± 0.4* | 0.71 ± 0.65 | 1.18 ± 0.4 | 0.41 ± 0.25* |
| f__Paraprevotellaceae | 6.77 ± 3.35* | 6.68 ± 7.45 | 9.81 ± 6.69 | 4.33 ± 4.29* |
| f__Verrucomicrobiaceae | 0.01 ± 0.03* | 0 ± 0 | 9.87 ± 11.46 | 0 ± 0** |
| f__F16 | 1.35 ± 1.06 | 0.75 ± 0.51 | 0.79 ± 0.42 | 1.45 ± 0.63 |
| f__Mycoplasmataceae | 0.05 ± 0.08 | 0.27 ± 0.16 | 0.21 ± 0.22 | 0.1 ± 0.11 |
| f__Peptostreptococcaceae | 0.31 ± 0.41 | 0.24 ± 0.39 | 0.06 ± 0.11 | 0.18 ± 0.31 |
| f__Dehalobacteriaceae | 0.33 ± 0.11* | 0.39 ± 0.11 | 0.24 ± 0.17 | 0.49 ± 0.12* |
| f__Peptococcaceae | 0.1 ± 0.06* | 0.11 ± 0.08 | 0.01 ± 0.03 | 0.15 ± 0.09* |
| f__Anaeroplasmataceae | 0 ± 0 | 0.08 ± 0.11 | 0 ± 0 | 0.05 ± 0.08** |
Values are expressed as mean ± SD. P-values were corrected for multiple testing with Benjamini–Hochberg false discovery rate correction (q-value). *P < 0.05, **P < 0.01, versus AD-Veh group. WT-Veh (4 males and 1 female), WT-NR (4 males and 2 females), AD-Veh (2 males and 1 female), AD-NR (2 males and 1 female), 12-month-old.