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. 2022 Sep 28;5(9):e2233730. doi: 10.1001/jamanetworkopen.2022.33730

Table 3. Classification of the Association Between Influenza Vaccination and COVID-19 Outcomes Based on Receipt of PHE.

2019-2020 Cohort
Vaccinated Unvaccinated
No. of individuals (%) 1 229 487 (53.9) 1 050 318 (46.1)
SARS-CoV-2 infection
No. of events (%) 2584 (0.21) 2745 (0.26)
HR (95% CI) 0.79 (0.75-0.83) 1 [Reference]
PHE 2018-2019, fully adjusted HR (95% CI)
Yes 0.62 (0.52-0.74)
No 0.81 (0.76-0.87)
SARS-CoV-2–associated hospitalization
No. of events (%) 992 (0.08) 980 (0.09)
HR (95% CI) 0.84 (0.77-0.92) 1 [Reference]
PHE 2018-2019, fully adjusted HR (95% CI)
Yes 0.64 (0.47-0.87)
No 0.86 (0.77-0.97)
SARS-CoV-2–associated death
No. of events (%) 428 (0.03) 441 (0.04)
HR (95% CI) 0.82 (0.72-0.93) 1 [Reference]
PHE 2018-2019, fully adjusted HR (95% CI)
Yes 0.46 (0.28-0.74)
No 0.78 (0.66-0.92)
SARS-CoV-2–associated hospitalization or death
No. of events (%) 1104 (0.09) 1093 (0.10)
HR (95% CI) 0.84 (0.77-0.91) 1 [Reference]
PHE 2018-2019, fully adjusted HR (95% CI)
Yes 0.66 (0.49-0.88)
No 0.85 (0.76-0.95)

Abbreviations: HR, hazard ratio; PHE, periodic health examination.