Table 1. Indications for Folate Prescribing and Folate Drug Interactions.

Medication group	Generic name	Folic acid indication
Antimetabolite	Methotrexate	Rheumatoid arthritis,15,16 psoriasis.
Proton pump inhibitor	Dexlansoprazole, esomeprazole, lansoprazole, lansoprazole/naproxen, omeprazole, omeprazole/sodium bicarbonate, pantoprazole, rabeprazole
Antihistamine and antacid	Cimetidine, cimetidine/dextrose, cimetidine/sodium chloride, famotidine, nizatidine, ranitidine, ranitidine/sodium chloride
Antidiabetes	Metformin
Antirheumatic	Sulfasalazine
Antimicrobial	Sulfamethizole/trimethoprim, sulfamethoxazole/trimethoprim
Antibiotic	Trimethoprim
Antidepressant	Citalopram, escitalopram, fluoxetine, olanzapine, fluvoxamine, paroxetine, sertraline, desvenlafaxine, venlafaxine, levomilnacipran, duloxetine, doxepin, trazodone, isocarboxazid, phenelzine, tranylcypromine, amitriptyline, bupropion, fluoxetine, mirtazapine, nefazodone, vilazodone, vortioxetine, amitriptyline, amoxapine, clomipramine, desipramine, imipramine, maprotiline, nortriptyline, protriptyline, trimipramine
Antiepileptic	Acetazolamide, carbamazepine, divalproex, eslicarbazepine acetate, ethanol/phenobarbital, ethosuximide, ethotoin, felbamate, fosphenytoin, lacosamide, levetiracetam, methsuximide, oxcarbazepine, perampanel, phenobarbital, phenytoin, primidone, rufinamide, tiagabine, topiramate, valproate sodium, valproic acid, vigabatrin, zonisamide	Any use. May reduce folate, but folate may also impede mechanism of action.a

^a Effects are not well understood. The prescriber may use discretion in supplementation with folic acid when prescribing antiepileptic drugs.¹⁷