Table 2. Baseline Characteristics of Study Cohort (N = 866 586).
| Variable | No. (%) |
|---|---|
| Age, y | |
| 18-29 | 223 294 (25.77) |
| 30-39 | 236 551 (27.30) |
| 40-49 | 144 852 (16.72) |
| 50-59 | 171 593 (19.80) |
| ≥60 | 90 296 (10.42) |
| Female | 704 514 (81.30) |
| Male | 162 072 (18.70) |
| Prior suicide attempt and intentional self-harm | 1283 (0.15) |
| Medication | |
| Folic acid | 125 870 (14.52) |
| Antimetabolite (methotrexate) | 161 789 (18.67) |
| Proton pump inhibitor | 151 295 (17.46) |
| Antihistamine and antacid | 33 046 (3.81) |
| Antidiabetic | 60 913 (7.03) |
| Antirheumatic | 15 992 (1.85) |
| Antimicrobial | 76 298 (8.80) |
| Antibiotic | 5565 (0.64) |
| Antidepressant | 208 804 (24.10) |
| Antiepileptic | 47 016 (5.43) |
| Any of above drugs excluding folic acid | 464 541 (53.61) |
| Comorbidity or other diagnosis | |
| Substance use disorder | 41 019 (4.73) |
| Depression | 103 954 (12.00) |
| Anxiety | 126 425 (14.59) |
| Attention-deficit/hyperactivity disorder | 17 680 (2.04) |
| Bipolar disorder | 21 234 (2.45) |
| Schizophrenia | 7301 (0.84) |
| Sleep disorder | 82 004 (9.46) |
| Crohn disease | 10 369 (1.20) |
| Celiac disease | 3177 (0.37) |
| Pain | 399 019 (46.04) |