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. 2022 Sep 15;13:947216. doi: 10.3389/fgene.2022.947216

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Copyright © 2022 Wang, Wu, Shi, Ji, He, Dong, Wang, Zhang and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Tumor classification based on the necroptosis-related DEGs; Univariate Cox regression analysis and LASSO analysis. (A) 498 PTC patients were grouped into two clusters according to the consensus clustering matrix (k = 2); (B) Principal Component Analysis (PCA) of RNA expression profile in TCGA cohort; (C) Kaplan–Meier curves of overall survival (OS) in two clusters; (D) Heatmap and clinicopathologic features of the two clusters; (E) Forest plot showing the result of univariate Cox regression analysis of OS, 16 genes with p < 0.2; (F) Cross-validation for tuning parameter selection in LASSO regression (G) LASSO analysis of 16 prognostic pyroptosis-related genes.